Seth L Alper Selected Research

Mucin-1 (CA 15-3 Antigen)

1/2021	Plasma Mucin-1 (CA15-3) Levels in Autosomal Dominant Tubulointerstitial Kidney Disease due to MUC1 Mutations.
6/2020	A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.
1/2019	Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.
1/2018	Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease.
10/2015	Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management--A KDIGO consensus report.
3/2013	Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.

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Seth L Alper Research Topics

Disease

12	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 01/2020 - 01/2002
11	Kidney Diseases (Kidney Disease) 01/2023 - 02/2015
8	Sickle Cell Anemia (Hemoglobin S Disease) 01/2023 - 01/2016
8	Neoplasms (Cancer) 01/2021 - 01/2002
7	Autosomal Dominant Polycystic Kidney (ADPKD) 05/2024 - 02/2002
7	Dehydration (Water Stress) 12/2022 - 06/2007
5	Hydrocephalus (Hydrocephaly) 04/2024 - 08/2017
5	Diarrhea 01/2024 - 01/2002
5	Inflammation (Inflammations) 01/2023 - 01/2013
4	Anaphylaxis (Anaphylactic Shock) 10/2022 - 11/2016
4	Brain Edema (Cerebral Edema) 10/2020 - 05/2007
4	Deafness (Deaf Mutism) 12/2016 - 01/2002
4	Goiter 12/2016 - 01/2011
4	Acidosis 11/2016 - 05/2007
3	Cysts 05/2024 - 03/2007
3	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/2023 - 02/2015
3	Fibrosis (Cirrhosis) 01/2021 - 01/2013
3	Peritoneal Fibrosis 01/2021 - 01/2012
3	Peritonitis 01/2018 - 01/2016
3	Hypertension (High Blood Pressure) 08/2017 - 11/2010
3	Ischemic Stroke 08/2017 - 07/2015
3	Cystic Fibrosis (Mucoviscidosis) 01/2017 - 08/2011
3	Pendred syndrome 12/2016 - 01/2011
3	Nephrolithiasis 01/2016 - 03/2008
3	Hemolytic Anemia 10/2015 - 05/2007
2	COVID-19 01/2023 - 06/2020
2	Hypoxia (Hypoxemia) 01/2022 - 01/2010
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 11/2020 - 06/2020
2	Acute Lung Injury 11/2020 - 06/2020
2	hereditary Xerocytosis 01/2019 - 01/2017
2	Renal Insufficiency (Renal Failure) 01/2018 - 05/2017
2	Hyperoxaluria (Oxaluria) 01/2017 - 01/2016
2	Anemia 01/2014 - 05/2011
2	Hearing Loss (Hearing Impairment) 05/2013 - 08/2009
2	Osteopetrosis 02/2013 - 01/2002
2	Heart Failure 01/2013 - 01/2011
2	Sensorineural Hearing Loss 01/2011 - 01/2011
2	Insulin Resistance 12/2005 - 05/2004
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 09/2004 - 10/2003
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 05/2024
1	Infections 01/2023
1	Cytokine Release Syndrome 01/2023
1	Chronic Renal Insufficiency 01/2023
1	Weight Loss (Weight Reduction) 01/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2023

Drug/Important Bio-Agent (IBA)

12	CationsIBA 05/2024 - 02/2002
9	dirhodium tetraacetate (DRTA)IBA 05/2017 - 01/2002
8	Proteins (Proteins, Gene)FDA Link 03/2023 - 02/2002
8	Apolipoprotein L1IBA 01/2023 - 02/2015
7	AcidsIBA 01/2022 - 01/2002
6	Peptides (Polypeptides)IBA 03/2024 - 03/2007
6	ChloridesIBA 01/2024 - 01/2002
6	Mucin-1 (CA 15-3 Antigen)IBA 01/2021 - 03/2013
6	Phosphotransferases (Kinase)IBA 08/2017 - 10/2003
5	K Cl- CotransportersIBA 03/2020 - 03/2007
5	Chloride-Bicarbonate AntiportersIBA 02/2017 - 01/2002
5	AnionsIBA 01/2016 - 03/2008
4	Adenosine Triphosphatases (ATPase)IBA 01/2020 - 01/2002
4	Erythrocyte Anion Exchange Protein 1 (Band 3 Protein)IBA 02/2017 - 01/2002
4	OxalatesIBA 01/2017 - 03/2008
3	TRPP Cation ChannelsIBA 05/2024 - 03/2007
3	CytokinesIBA 12/2022 - 01/2016
2	ChromatinIBA 04/2024 - 01/2019
2	LipopolysaccharidesIBA 01/2023 - 01/2014
2	Endothelin-1 (Endothelin 1)IBA 01/2023 - 12/2022
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2023 - 01/2014
2	4-Aminopyridine (4 Aminopyridine)FDA Link 10/2022 - 11/2016
2	Grammostola spatulata MTx4 proteinIBA 01/2022 - 01/2010
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 06/2009
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2014
2	NucleotidesIBA 01/2021 - 06/2009
2	fostamatinibIBA 11/2020 - 06/2020
2	Syk KinaseIBA 11/2020 - 06/2020
2	Biomarkers (Surrogate Marker)IBA 06/2020 - 01/2016
2	OvalbuminIBA 01/2019 - 11/2016
2	Bumetanide (Bumex)FDA LinkGeneric 08/2017 - 07/2015
2	senicapocIBA 01/2017 - 01/2016
2	xylometazoline (stas)IBA 12/2016 - 04/2013
2	PotassiumIBA 01/2016 - 06/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 07/2015
2	Oxygen (Dioxygen)IBA 07/2015 - 01/2002
2	IodidesIBA 05/2013 - 01/2011
2	Messenger RNA (mRNA)IBA 01/2013 - 06/2009
2	Carbonic Anhydrase IIIBA 11/2010 - 01/2002
2	Insulin-Like Growth Factor I (IGF-1)IBA 03/2007 - 09/2004
2	Insulin-Like PeptidesIBA 03/2007 - 09/2004
1	ColforsinIBA 05/2024
1	yoda-1IBA 05/2024
1	AntibodiesIBA 01/2023
1	Clopidogrel (Plavix)FDA Link 01/2023
1	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2023
1	proteoliposomesIBA 01/2023
1	AldosteroneIBA 01/2023
1	CreatinineIBA 01/2023
1	Lipid Bilayers (Lipid Bilayer)IBA 01/2023
1	AlbuminsIBA 01/2023

Therapy/Procedure

10	Therapeutics 01/2021 - 01/2002
4	Peritoneal Dialysis 01/2017 - 01/2012
1	Combination Drug Therapy (Combination Chemotherapy) 05/2024
1	Renal Dialysis (Hemodialysis) 01/2023